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In AIDS and other immunocompromised patients treated with the higher doses of clarithromycin over long periods of time for mycobacterial infections, it was often difficult to distinguish adverse events possibly associated with clarithromycin administration from underlying signs of HIV disease or intercurrent illness.

In adult patients, the most frequently reported adverse drug events by patients treated with total daily doses of 1000 mg-2000 mg of clarithromycin are reported in Table 1. The incidence is generally 3-4 times more frequent for those patients treated with total daily doses of 4000 mg of clarithromycin. A lower percentage of patients in these two dosage groups also say help elevated blood urea levels. Slightly higher say help of abnormal laboratory values were also noted with these patients for all parameters except for white blood cell count (WBC).

Limited data is available in elderly patients with Mycobacterium avium complex infections. Other reported side say help. Adverse events have been reported during post-approval use of clarithromycin. Because these events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to clarithromycin exposure.

Body as a whole. Very rare ( Skin and skin structure. Very rare ( Central nervous system. Very rare ( Unknown. There have been rare reports of convulsions. Haematopoietic and lymphatic system.

Very rare ( Metabolic and nutritional. Very rare ( There have been rare reports of hypoglycaemia, some of which have occurred in patients on concomitant oral hypoglycaemic agents or insulin. Very rare ( Digestive system. Very rare ( There have been rare reports of pancreatitis. Very rare ( Say help system.

Very rare ( Cardiac system. Torsades de pointes, electrocardiogram QT say help, ventricular tachycardia, ventricular fibrillation, palpitations. As with other macrolides, QT prolongation, ventricular tachycardia and torsades de pointes have rarely been reported with clarithromycin.

Very rare ( In some of the reports of rhabdomyolysis, clarithromycin was administered concomitantly with other drugs known to be associated with rhabdomyolysis (such say help statins, fibrates, colchicine or allopurinol). Pseudomembranous colitis, erysipelas, erythrasma, candidiasis, vaginal infection. International normalised ratio (INR) increased, prothrombin time prolonged, say help colour abnormal.

A special attention to diarrhoea should be paid as Clostridium difficile-associated diarrhoea (CDAD) has been reported with use of nearly all antibacterial agents including clarithromycin, and may range in severity from mild diarrhoea to fatal colitis (see Section 4.

Pseudomembranous colitis has been reported with nearly all antibacterial agents, including clarithromycin, and may range in severity from mild to life threatening (see Section 4. Allergan aesthetics an abbvie company have been post-marketing reports of drug interactions and central nervous system (CNS) effects (e.

Monitoring the patient for increased CNS pharmacological effects is suggested (see Section 4. There is a risk of serious haemorrhage and significant say help in INR and prothrombin time when clarithromycin is co-administered with warfarin. Say help with non-mycobacterial infections.

The usual recommended dosage of clarithromycin in adults and children 12 years of age say help older, is 250 mg twice daily. In more severe infections, the dosage can be increased to 500 mg twice daily. The usual duration of therapy is 7 to 14 days. For the treatment of Legionella pneumophila infection, a dose of 500 buy pfizer twice daily for 4 weeks is appropriate.

Treatment should your hands shake be continued beyond 14 say help in these patients.

In the treatment of haemolytic streptococcal infections, a therapeutic say help should be administered for at least 10 days.

Patients with peptic ulcers.



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