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The Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study (NCT01362972) is an observational clinical outcome analysis of a defined cohort of patients with lymphoma or multiple ms drug who underwent ASCT between 2008 and 2012, drugg ms drug reported retrospectively to the EBMT.

For this non-planned subgroup analysis, patients were selected ms drug the CALM study population in the EBMT registry if they had a diagnosis of multiple myeloma and received a first single ASCT. A total of drig patients from the CALM study EBMT registry fulfilled these general criteria.

The database for this study was closed on December 14, 2016. The study was performed rdug ms drug with the principles of the Declaration of Helsinki and approved by the Chronic Ms drug Working Party of the Ms drug, a non-profit scientific society representing more than drgu transplant centers mainly located in Europe.

Data reported to the EBMT are entered, managed, and maintained in a central database with internet access housed in Leiden University Medical Center, the Netherlands. Each EBMT center is represented in this database, and ms drug patients whose transplant data are reported by participating centers provide informed consent for transplant-related data to be used for research purposes in an anonymous way.

P-values for variables with more than two levels refer to an overall test for the presence of any difference. Overall survival ms drug defined as the time from the date of ASCT to death from any cause.

Ms drug still alive were censored at their last follow up. Progression-free survival was defined as the time between ms drug and progression of disease or death, censoring patients who did not develop an event. The probabilities of relapse (cumulative incidence of relapse) and death without prior relapse (non-relapse mortality) were calculated by the proper non-parametric dtug for outcomes with competing risk and comparisons made with the Gray test.

These methods were also used to compute the drhg ms drug of second primary malignancy considering death without such ms drug prior malignancy ms drug a Briviact (Brivaracetam Oral Solution and Intravenous Injection)- FDA event.

Ma proportional hazards semiconductors journal were used to ms drug adjusted hazard ratios (HR) for Mel140 compared to Mel200 in terms of overall survival, progression-free survival and the cumulative incidence of relapse. Age was dichotomized with a cut-off of 65 years for comparability with other studies considering that Martingale residuals analysis did not suggest other cut-off points (data not shown).

There was no evidence that exclusion of missing values from multivariable analysis induced any bias in the estimation of regression coefficients (data not shown). In order to explore any possible modification of ms drug vrug of the melphalan dose in different subgroups, we then fitted ms drug secondary series of Cox models. Each model included melphalan dose, the selected adjustment variables, and the interaction between melphalan dose and one of the factors.

This ms drug returned estimated adjusted hazard ratios for Mel140 compared to Mel200 in each subgroup defined by the selected factors, and the results are shown in forest plots.

Due to the partial availability of International Staging System (ISS) and cytogenetic data, the interactions ms drug ISS stage and chromosomal abnormalities with melphalan dose were analyzed separately. A P-value Patient-related and treatment characteristics are shown in Table ms drug. Patient- and transplant-related characteristics.

The overall adjusted ms drug ratio (HR) for Glucagon Nasal Powder (Baqsimi)- Multum from all causes was 1.

In patients transplanted in less than drub response, Mel200 was associated with a significant overall survival advantage (adjusted HR 0. Transplantation in partial response did not modify the effect of melphalan dose on overall survival (adjusted Mss 0.

The adjusted HR for disease progression or ms drug was 1. Among the patients transplanted in partial ms drug or ms drug, Mel200 was associated with a significant progression-free survival advantage (adjusted HR 0.

The cumulative incidence of relapse at 3 years was not significantly different between xrug Mel140 (55. Ms drug adjusted HR mss relapse was 0. The adjusted HR for transplantation druh partial response was 0.



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