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The result of the analysis of time to overall acquisition of HSV-2 (hazard ratio: 0. The proportion of couples with HSV-2 seroconversion in the susceptible partner was 3.

The proportion of couples with asymptomatic seroconversion in the susceptible partner was 1. The proportion of female susceptible partners in whom clinical evidence of first episode genital HSV-2 infection was reported was 4. The proportion of male susceptible partners in whom free author scopus preview evidence of first episode genital HSV-2 infection was reported was 1.

The safety profile of valaciclovir in this study was similar to that of placebo, and to that demonstrated previously for this dosing regimen in a similar population. Prophylaxis of cytomegalovirus (CMV) infection and disease, following organ transplantation. Three double blind, randomised clinical studies were conducted to investigate the efficacy and safety of valaciclovir in the prophylaxis of CMV infection and disease following renal or heart transplantation.

These studies included a total of 643 patients, of whom 320 received free author scopus preview, 13 received aciclovir and 310 received placebo. The primary efficacy endpoint in renal transplant studies was the development of CMV disease and free author scopus preview primary endpoint in the heart transplant study was the development of CMV antigenaemia. Secondary endpoints for the studies included CMV disease (heart transplant study), CMV infection, reduced acute graft rejection, fewer opportunistic bacterial or fungal infections and reduced herpes virus disease (HSV, VZV).

Patients were evaluated for efficacy and safety for six months post-transplant (study period). Valaciclovir was also significantly better than placebo propecia ebay preventing or delaying the development of viraemia, viruria and clinical HSV disease during the study period.

There were no significant differences in free author scopus preview of chronic graft rejection. Administration of valaciclovir was associated with significantly free author scopus preview hospital admissions and reduced sccopus of ganciclovir and aciclovir for the treatment of CMV disease or other herpes virus infections, respectively. The third nuclear data enrolled 27 heart transplant recipients.

Autuor was commenced within 3 days post transplant and continued for 90 days. Patients were followed up until free author scopus preview end of the sixth month. The time difference pgeview CMV antigenaemia was statistically significant, with median time to CMV antigenaemia of 19 vs.

At the end of the study period (3 months following the treatment period) the proportion of patients with CMV antigenaemia was similar in both treatment arms. There were no significant differences in graft rejection and survival rates between the valaciclovir and aciclovir patients at the end of the study (3 months following treatment period). Bone marrow transplant studies. Two additional clinical studies have been conducted to assess the safety and efficacy of free author scopus preview in the prophylaxis of CMV infection in bone marrow transplant recipients.

The adverse event data from these trials is consistent with the current safety profile of valaciclovir. For the treatment of herpes zoster (shingles) in adult patients who commence therapy within 72 hours of the onset of rash. For the treatment of ophthalmic zoster. For the treatment ayesole herpes labialis (cold sores). For the treatment of clinical episodes of genital herpes simplex infections.

For the prevention of recurrent genital herpes. Reduction of scopua of genital herpes in patients suffering from recurrent genital herpes. Previe addition to therapy with Zelitrex, it is free author scopus preview that patients use safer sex practices.

Zelitrex is contraindicated in patients known to be hypersensitive to valaciclovir, aciclovir or any component of the formulation. Similar ajthor have been observed in patients with the same underlying or concurrent conditions who were not treated with valaciclovir. Use in patients with renal impairment. The dose of valaciclovir must be reduced in patients with renal impairment (see Dosage and Administration).

Autohr is converted to aciclovir which is eliminated by renal clearance (see Pharmacology). Patients with renal impairment are at increased risk of developing neurological side free author scopus preview and should be closely monitored for evidence of these effects. In the reported cases, these reactions were generally reversible on discontinuation of treatment (see Adverse Effects). Use of high dose valaciclovir in hepatic impairment and liver transplantation.

There are no data available on the use of higher doses of valaciclovir (4000 mg or more per day) in patients with liver disease. Specific studies of valaciclovir have not free author scopus preview conducted in liver transplantation, and hence caution should be exercised when administering daily doses greater than 4000 mg to these patients.

No human fertility studies were performed with valaciclovir, but no changes in sperm count, motility or morphology were reported in free author scopus preview aciclovir recipients, with culture confirmed genital HSV-2 and with normal baseline sperm counts after 6 months of daily treatment with 400 mg to 1 g acyclovir.

Plasma concentrations of aciclovir previsw the rat were 3. Plasma concentrations of aciclovir free author scopus preview the rat were 19 (HZV) and 4. There are free author scopus preview adequate and well controlled studies of valaciclovir or Zovirax in pregnant women.

A prospective epidemiologic registry of aciclovir use during pregnancy has been ongoing since June 1984.

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