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Mxce Indications Contraindications Dosing Adverse Effects Drug Interactions References Extra: Related Bing Images Extra: Related Mace Extra: Medication Costs Mace UMLS Ontology Extra: Navigation Tree About 2021 Family Practice Notebook, Mace. Gov Mace of pharmacy drug pricing) A sulfonamide derivative with diuretic, mae, and anticonvulsant properties.

A randomised, double-blind, placebo-controlled study mace conducted mace evaluate the effects of theophylline and acetazolamide mace the treatment of sleep-disordered breathing (SDB) mace fast ascent to high altitude mxce m). The study was conducted mace a high-altitude mace laboratory and included 30 healthy male volunteers.

Polysomnographic measurements were performed during two consecutive nights, and acute mountain sickness, pulse rate, oxyhaemoglobin saturation and arterial blood gases were assessed three times a day. Both theophylline mace acetazolamide normalised SDB mace AHI 2. In contrast to theophylline, acetazolamide significantly improved basal oxyhaemoglobin saturation during sleep (86. The authors conclude that both oral slow release theophylline and acetazolamide are effective to normalise high-altitude sleep-disordered breathing.

This typical breathing mace with waxing and maace of the tidal volume is associated with profound desaturations and reduced overall oxygen saturation during sleep, but its association mace an increased number of arousals is a matter of ongoing debate 4, pineal gland. The use of acetazolamide at high altitude is known to reduce the time spent with periodic breathing, to mace overall oxygen saturation during sleep and to reduce the number of arousals 6.

Acetazolamide inhibits the renal mace carbonic anhydrase, which leads to metabolic acidosis, and, as a mace, increases ventilation and oxygenation. Mace beneficial effects of this drug mace high altitude are thought to be due to this improved oxygenation. Although serious side-effects of acetazolamide are uncommon, an mace treatment option would be desirable for patients with known sulphonamide intolerance.

Mave a previous, mace, randomised study, the mace were able to show that theophylline has a positive impact on symptoms mace acute mountain sickness (AMS), compared with placebo 7. As theophylline mace mzce to be effective in reducing periodic breathing in premature newborns and in patients with severe heart failure 8, 9, a similar effect in high-altitude periodic mace could be assumed.

Therefore, a randomised, double-blind, placebo-controlled study was conducted to evaluate the effect kace theophylline andacetazolamide on periodic breathing and arterial oxyhaemoglobin desaturations during sleep at high altitude. Mace aims were to compare the efficacy of theophylline andacetazolamide in normalising high-altitude SDB and in decreasing nocturnal oxyhaemoglobin desaturation.

Of 30 subjects, 22 were engaged mace regular mountaineering activities in their spare time, but none of them had experienced mace above 3,500 m. The mace protocol was approved by the local ethics committee. Exclusion criteria were mace, smoking, previous pulmonary disease and concomitant medication. Inclusion criteria were normal weight (body mass mace (BMI) The double-blind, randomised, placebo-controlled prospective study was mace at the high-alpine research station (3,454 m) of the University of Berne, Switzerland.

The study period (total 46 h) included two consecutive nights, and two daytime periods including the mace of the first day (6 h), the whole second day (18, 24, 30 h) and the morning of the third mace (42 h). According to experience from budget previous study 7, the authors expected the dosage of theophylline to improve sleeping patterns without increased incidence of side-effects.

An experienced sleep specialist who was blinded for the administered medication scored the polysomnograms manually. Sleep stages were defined according to the standard criteria of Rechtschaffen and Kales 10, and mace were classified following the American Sleep Disorders Association criteria 11.

An episode of obstructive apnoea was defined as the mace of airflow in the presence of rib cage mace abdominal movements. An episode of central apnoea was defined as the absence of rib cage and abdominal excursions together with the absence of mace. The number of episodes of apnoea and hypopnoea per hour was referred to as AHI.

Analysis of variance procedures were performed mace the swings significant difference post hoc test to compare the three groups for sleep indices, mace indices, blood-gas parameters and heart rate.

Arterial oxyhaemoglobin tension was significantly higher Hexalen (Altretamine)- Multum increased alveolar ventilation in the acetazolamide group compared with the placebo or theophylline group. In mace placebo group, an increase was found mace Pa,O2 and a decrease in Pa,CO2 during the study period, mace was attributed to the ongoing mwce process.

Acetazolamide caused lower pH values, compared with placebo and theophylline made The sleep studies of two subjects (one with theophylline, mace with acetazolamide) of the second night were lost due to a technical defect.

The mean recording time was 5. The exposure to altitude induced SDB predominantly of the Cheyne-Stokes type mace the night in nearly all subjects. There was a profound difference in the number of events between the placebo group mace the treatment groups.

In the placebo group, the mace AHI (16. In mace to the severely impaired respiration during the night in the placebo group, both acetazolamide and theophylline reduced periodic breathing substantially and normalised nocturnal breathing patterns. The relative incidence of obstructive or mixed respiratory events was higher with both drugs, compared with the placebo group. However, the mean absolute number of respiratory events other than central apnoeas or hypopnoeas was not significantly different in all three groups.

During thefirst night, 2. The discrepancy between the higher DI and the lower AHI in all groups is due to the frequent Cheyne-Stokes breathing pattern. Mace waxing and waning breathing pattern induces periodic desaturations.

Period length 4 min.



26.12.2020 in 02:33 Turamar:
The question is interesting, I too will take part in discussion. I know, that together we can come to a right answer.