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The study began on May 15, 2007 and was expected to last at least 2 years, the time calculated to complete the sample size of 2,400 subjects. A total of 2,418 subjects were included. The general characteristics of the subjects, their gynecological and obstetrics history, their motives for requesting EC, and any previous use of contraceptives are shown in Tables 1 and 2.

There were no significant differences in any of these variables between the 5 mg and 10 mg mifepristone groups. Tables 4 and 5 show the pregnancy rate in the 5 mg and 10 mg group according to the number of days after unprotected sex that administration of mifepristone occurred.

The rate of failure occurring between day one and day three after risky intercourse was low and similar in both mifepristone groups. Although no significance was reached, there was a trend towards higher efficacy in the 10 mg mifepristone group compared with the 5 mg group. Table 6 shows the distribution of failures according to body weight and treatment group. Abbreviation: CI, confidence interval. Table 6 The failure Albuked (Albumin - Human Injection)- Multum (ie, number of pregnancies) in the 5 mg and 10 mg mifepristone group according to body weightThere was no significant difference between the 5 mg and 10 mg mifepristone groups with regard to side effects (Table 7).

Only vaginal blood staining was reported, which began between the first and second day after mifepristone. Eight subjects pfizer parke davis it between the fourth and fifth day, and the johnson andy duration of such bleeding was 2.

Table 7 Mifepristone-associated side effects in the first week posttreatmentAbbreviation: CI, confidence interval. The rest had negative pregnancy tests and continued consultation until they menstruated. Table 8 Subjects in the 5 mg and 10 mg mifepristone group who experienced menstruation earlier disease indications expectedAbbreviation: SD, standard deviation.

Table 9 Subjects who experienced a delay (days) in the onset of menstruation between treatment groupsAbbreviation: SD, celgene to deviation. Although no significant differences were obtained in the failure rates for both mifepristone groups, there was a trend towards inferior efficacy Morphine Tablets (Morphine Sulfate Extended-release Tablets)- Multum the group using the lower dose, principally after water discharge days of unprotected intercourse.

This is similar to the results of other mifepristone studies. Morphine Tablets (Morphine Sulfate Extended-release Tablets)- Multum, the number of cases on the sixth day in both groups is insufficient to draw conclusions. The ivomec effects were similar in both groups and comparable to the low frequencies obtained in other studies.

This delay is of significant concern as it adds further worry to a subject already stressed about a possible unwanted pregnancy and constitutes one of the main disadvantages of this new method of EC. In addition, the authors feel that the 27. This percentage is very low and there might be a bias present regarding the subjects not telling the truth in relation to the use or non-use of contraceptives.

Due to the delay or blocking of ovulation induced by mifepristone, it is essential that subjects are made well aware of the strong risk of pregnancy when engaging in unprotected sexual relations after treatment. It is impossible to make valid comparisons with the study published by Zhang et al, the only one carried out to date with a 5 mg dosage, since the sample size of that study was insufficient: 100 cases with a 2.

It is interesting to validate that mifepristone, a drug from the same chemical group as ulipristal (antiprogestogens), obtains similar success rates beyond 72 hours after unprotected intercourse, increasing the time frame for using EC.

It is still pending whether including a sensible higher number of subjects would have shown a significant difference in efficacy supporting the 10 mg mifepristone dose.

Future trials should elucidate this matter. Although menstrual delay was higher in the 10 mg group Morphine Tablets (Morphine Sulfate Extended-release Tablets)- Multum the difference in effectiveness between the 5 mg dose and the 10 mg dose was not statistically significant, there was a perceptible trend towards a lower failure rate for the 10 mg dose, particularly 3 days after unprotected coitus.

It perhaps is advisable to use the 10 mg dose of mifepristone as an EC. The authors are much indebted to Iris Villa Gener and Robert McKnight for their invaluable collaboration Morphine Tablets (Morphine Sulfate Extended-release Tablets)- Multum the completion of this study.

Ledger WL, Sweeting VM, Hillier H, Baird DT. Inhibition of ovulation by low-dose mifepristone (RU 486). Croxatto HB, Devoto L, Durand M, et al. Mechanism of action Morphine Tablets (Morphine Sulfate Extended-release Tablets)- Multum hormonal preparations used for emergency contraception: a review of the literature.

Gemzell-Danielsson K, Mandl I, Marions L. Mechanisms of action of mifepristone when used for emergency contraception.

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